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Apigenin is a compound found in a wide variety of herbs, fruits and vegetables. It is a naturally occurring flavonoid that inhibits CD38, and crucially, in turn boosts NAD+ levels. It is a particularly interesting substance for health and longevity researchers, with extensive studies that have focused on its anti-inflammatory, antioxidant, anti-stress, pro-mitochondrial, antineoplastic, neuroprotective, and broad adaptogenic effects. Androgenic effects have also been found, assisting the body in the production of protective androgens that keep estrogen, cortisol, and various stress chemicals in check.

Apigenin has been found to possess numerous potential health-related benefits including:

Supports prostate health
Promotes glucose metabolism
Maintains nervous system function
Supports skin health
Anti-inflammatory abilities

How Apigenin Work?

The observed reduction in inflammation is understood to be due to its ability to suppress the release of numerous inflammatory mediators including inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2), Th1 cytokines interferon-gamma (IFN-γ), and interleukin-2 (IL-2).

Upon consumption of Apigenin, it is rapidly metabolized and released into the serum as glucuroside and sulfate conjugates. With a half-life of 92 hours, Apigenin is present in the blood up to 24 hours after initial ingestion. The anti-inflammatory effects of Apigenin are via the suppression of NO-synthase induction and COX2 enzymes in macrophages. There are also inhibitory effects on Interleukin-4 production. Apigenin has also been shown to potentially suppress TNFa elevations and potentially TNFa induced upregulation of adhesion molecules.